منابع مشابه
Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy.
Mitochondrial dysfunction is implicated in numerous cardiac disorders. It has been assumed that the functional defects are directly related to a decreased rate of mitochondrial ATP production, but recent studies have challenged this idea. Here, we used mice with tissue-specific knockout of mitochondrial transcription factor A (Tfam) that leads to progressive cardiomyopathy. The role of changes ...
متن کاملStable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca -evoked release of catecholamine
Moore, Johnnie M., Jason B. Papke, Anne L. Cahill, and Amy B. Harkins. Stable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca -evoked release of catecholamine. Am J Physiol Cell Physiol 291: C270–C281, 2006. First published February 8, 2006; doi:10.1152/ajpcell.00539.2005.—Synaptotagmin (syt) I is a Ca -binding protein that is well accepted as a major sensor for Ca -regulated re...
متن کاملTyrosine: effects on catecholamine release.
Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments that accelerate nigrostriatal firing, but not in untreated rats. We examined the possibility that the amino acid might actually enhance dopamine release in untreated animals, but that the technique of measuring striatal dopamine metabolism was too insensitive to demonstrate such an effect. Dopam...
متن کاملrelease in catecholamine-induced cardiac hypertrophy
Objective: Catecholamines that accompany acute physiological stress are also involved in mediating the development of hypertrophy and failure. However, the cellular mechanisms involved in catecholamine-induced cardiac hypertrophy, particularly Ca + handling, are largely unknown. We therefore investigated the effects of cardiac hypertrophy, produced by isoprenaline, on INa/Ca and sarcoplasmic re...
متن کاملExocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells.
Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, allowing rapid retrieval from the plasma membrane of fused vesicles for future use. This can be a much faster mechanism for membrane recycling than classical clathrin-mediated endocytosis. During a fast exo-endocytotic cycle, the vesicle membrane does not fully collapse into the p...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1976
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)60776-6